When Oklahoma Sooners (No. 13, 6-1) host the Ole Miss Rebels (No. 8, 6-1) on Saturday, Oct 25, 2025, the buzz centers on a clash that could reshape the Big 12 and SEC race. The showdown kicks off at 12 p.m. ET inside Gaylord Family Oklahoma Memorial Stadium in Norman, Oklahoma, and ABC will carry every snap. According to Fox Sports, the Sooners are 5.5‑point favorites at -110 odds, with an over/under set at 52.5 points. The implied line reads 29‑24 for Oklahoma, and a proprietary model assigns them a 66.9% win probability. Moneyline odds list OU at -202 versus Ole Miss +168.